Hordes of terrifying mythical creatures suddenly appear across the globe - a dragon perched on the statue of Christ the Redeemer overlooking Rio de Janeiro, a thirty-foot alligator lurking in the canals of Venice, a griffin slaughtering horses in Madrid, giant vampire bats, mermaids, gremlins. As the destruction and death toll escalate rapidly, Hellboy and the Bureau of Paranormal Research and Defence arm themselves for battle.